Purification of monoclonal antibodies by hydrophobic interaction chromatography under no-salt conditions
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چکیده
منابع مشابه
Purification of monoclonal antibodies by hydrophobic interaction chromatography under no-salt conditions
Hydrophobic interaction chromatography (HIC) is commonly used as a polishing step in monoclonal antibody purification processes. HIC offers an orthogonal selectivity to ion exchange chromatography and can be an effective step for aggregate clearance and host cell protein reduction. HIC, however, suffers from the limitation of use of high concentrations of kosmotropic salts to achieve the desire...
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ژورنال
عنوان ژورنال: mAbs
سال: 2013
ISSN: 1942-0862,1942-0870
DOI: 10.4161/mabs.25552